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Proceedings of the 11th NAPRECA Symposium August 9-12, 2005, Hôtel Panorama, Antananarivo, Madagascar
Local Organizing Committee International Organizing Committee
Prof. P. Rasoanaivo (Chairman) Prof. J. O. Midiwo (Executive Secretary) Dr. D. Ramanitrahasimbola (Secretary General) Dr. Abiy Yenesew (Programme Officer) Dr. V. Ramanandraibe (Treasurer) Dr. Solomon Derese (Member) Dr. D. Rakotondramanana (Member) Ms. O. Rakotonandrasana (Member)
The cover shows an indigenous Malagasy plant (Ravenela madagascariensis) which was used by Prof. Rasoanaivo during his plenary lecture to underline the importance of collaboration and partnership in research.
Edited by Prof. J. O. Midiwo (Executive Secretary) (jmidiwo@uonbi.ac.ke) Dr. Abiy Yenesew (Programme Officer) (ayenesew@uonbi.ac.ke) Dr. Solomon Derese (Member) (sderese@uonbi.ac.ke)
© 2006 A NAPRECA PUBLICATION
FOREWORD
Once again we present the book of proceedings of a NAPRECA Natural Products Symposium. This 11th NAPRECA symposium book of proceedings has many quality presentation reports which are a reflection of how research in the field in the region has developed by leaps and bounds since NAPRECA was formed in 1984. The improving quality of presentations from symposium to symposium is remarkable considering that the research facilities at NAPRECA member institutes have not changed concomitantly except in a few cases such as at the University of Botswana where requisite instrumentation is virtually optimal. Rather what must have increased is the level of collaboration intra-regionally and internationally. Such a bonding of researchers has been greatly helped by these biannual conferences which have been facilitated by our gracious donors-IPICS and IFS of Sweden, DAAD of Germany, UNESCO and OPCW as in the case of this symposium and the ten others before; we are highly indebted to them. With their support, many jobs were filled and much research carried out. Without their help, this project would not have been possible. We thank them.
NAPRECA Symposia continue to attract participants from many parts of the world other than the region alone. In this edition there are several reports by participants from industry and academia of Europe, America and Asia who took part very strongly in the proceedings at the symposium. Their presence at the meeting really added a lot of substance to the stature of the NAPRECA Symposia. We highly welcome their involvement with us which we hope will grow even stronger in the future. The papers in this book contributed by these senior researchers are quite informative and will help as good reference to the upcoming scientists in the region.
I would like to recognize the hard work by individuals which has led to the production of this informative booklet. Professor Phillipe Rasoanaivo and his team were wonderful hosts to all of us who attended the Symposium in Antananarivo, which they did a very good job organising. Special recognitions go to my colleagues, Dr. Abiy Yenesew and Dr. Solomon Derese for combing through the papers and making the document presentable.
Finally I would like to appreciate and thank all those who took part in the Symposium and have contributed articles for publication and welcome them all to participate with new results and ideas at the 12 th NAPRECA Symposium to be held in Kampala, Uganda in July 2007.
Prof. Jacob O Midiwo. NAPRECA Executive Secretary.
TABLE OF CONTENTS
| Author(s) | Title | Page | |||
Philippe Rasoanaivo, David Ramanitrahasimbola, Dina Rakotondramanana, Voahangy Ramanandraibe, Suzanne Ratsimamanga |
Natural Products and Drug Discovery through a Network of Partnerships
|
1-8 | |||
J. Ogweno Midiwo, A. Yenesew, B.F. Juma Kerubo L Omosa, Irene L Omosa, Daniel Mutisya. |
Phytochemical Evaluation of Some Kenyan Medicinal Plants
|
9-19 | |||
Dulcie A Mulholland, Neil R Crouch, Philip H Coombes, Joseph J Magadula and Milijaona Randrianarivelojosia |
Unusual triterpenoids from African medicinal plants
|
20-26 | |||
Bruno DAVID |
Drug Discovery, Natural Substances & Pharmaceutical Industry
|
27-34 | |||
Andrew Muzila, Titus A. M. Msagati, Berhanu Abegaz and Mathew M. Nindi |
Characterization of Geshodin-Metal Complexation by Electrospray-Mass Spectrometry
|
35-44 | |||
P. Okinda Owuor |
Advances in the Development of Reliable Black Tea Quality Parameters and Use in Selection of Superior Quality Plants
|
45-55 | |||
Gordon M. Cragg and David J. Newman |
Drug Discovery and Development from Natural Products: The Way Forward
|
56-69 | |||
Charles Mutai, Dennis Abatis, Constantinos Vagias, Dimitri Moreau, Christos Roussakis and Vassilios Roussis |
Two New Triterpenoids from Acacia mellifera (Vahl) Benth
|
70-76 | |||
Orech, F. O., T. Akenga, J. Ochora, H. Friis, J. Aagaard-Hansen |
Potential Toxicity of Some Traditional Leafy Vegetables Consumed in Nyang’oma Division, Western Kenya
|
78-87 | |||
Bekele Jembere, Daniel Getahun, Merid Negash, Emiru Seyoum |
Toxicity of Birbira (Milletia ferruginea) Seed Crude Extracts To Some Insect Pests As Compared To Other Botanical and Synthetic Insecticides
|
88-96 | |||
Benard F. Juma and Runner R. T. Majinda |
Three new compounds from Erythrina lysistemon and their antimicrobial, radical scavenging activities and their brine shrimp lethality
|
97-109 | |||
Maud Kamatenesi-Mugisha, Hannington Oryem-Origa, Olwa-Odyek & Dominic W. Makawiti |
Ethno-pharmacological screening of Vernonia amygdalina and Cleome gynandra traditionally used in Childbirth in Western Uganda
|
110-122 | |||
| F.A. Vries, H. El Bitar , I.R. Green, J.A. Klaasen, W.T. Mabusela , B. Bodo & Q. Johnson | An antifungal active extract from the aerial parts of Galenia Africana
|
123-131 | |||
Moswa J.L., Kapanda N., Mungende D.M, Okitolonda W, Mayangi M., Mihigo S., Mbale K |
Plants as an Important Source of Iron for the Treatment of Anaemia : Case of Justicia secunda
|
132-135 | |||
Rafatro Herintsoa, Robijaona Rahelivololoniaina Baholy, Razafimahefa Andriantiaray Solofoniaina, Rasoamahenina Antsa Mirindra, Ramanantsoa Edwinstaël Keller De Fernanto, Rakotoarimanana Hajatiana, Rakotondrabe Miora Harivony, Raminosoa Maminirina, Rakotozafy Armand, Ranaivoravo Jacques, Rajaonarison Jean-François, Ratsimamanga Suzanne, Gaston Lutete Tona, Gauthier Kahunu Mesia, Solomon Derese, Jacob O. Midiwo |
Screening of Plant Extracts for Searching Antiplasmodial Activity
|
136-144 | |||
P. Raharivelomanana, F. Laure, L. Charles And R. Faure |
LC/MS analysis of neoflavonoids: application for biodiversity investigation and bioactive molecule screening
|
145-153 | |||
Bodosoa H. Rakotonjatovo, Andoniala Rasolofoarimanga-H., Hanta Andriamanantoanina, Lalasoa Ranarivelo, Jean Maharavo, Luciano Ramaroson, Michel Ratsimbason |
A microfluorimetric method to screen marine products for antimalarial activity- Preliminary results
|
154-160 | |||
Abiy Yenesew, John T. Kiplagat, Eluid K. Mushibe, Solomon Derese, Jacob O. Midiwo, Jacques M. Kabaru, Matthias Heydenreich, Martin G. Peter |
Rotenoid derivatives from Kenyan Millettia and Derris species as larvicidal agents
|
161-168 | |||
Marta Andriantsiferana, Nirina R. Andriamaharavo, Christian R. Razafindrabe, Cecchini Harisoa, Parfait Rasendra, Martin Garraffo,Thomas Spande and John Daly |
New Lipophilic Alkaloids from Mantella frogs collected in Madagascar
|
169-186 | |||
F O Shode, R T Oyede, J K Adesanwo, and H Baijnath |
Extractives from Heteropyxis natalensis
|
187-192 | |||
F O Shode |
From Griseofulvin to Substituted Xanthones via Deoxygrisans
|
193-200 | |||
T.Sivakumar, R.Kanagasabai, R.Sampath kumar, P.Perumal , P.Sivakumar M.Gupta, U. K. Mazumder |
Evaluation of Anti-inflammatory activity and toxicity related studies of Chloroxylon sweitenia in standard animal models
|
201-213 | |||
Pierre Tane, Simplice D. Tatsimo, Godfred A. Ayimele and Joseph D. Connolly |
Bioactive metabolites from Aframomum species
|
214-223 | |||
|
Successful Drug Discovery from Natural Products: Methods and Results
|
224-232 | |||
|
Natural Products from around the World
|
233-242 |
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